In vitro pharmacological attributes and metabolite’s fingerprinting of Conocarpus lancifolius

Search for safe antioxidants and novel nutraceuticals urged to evaluate the antioxidant, anti-acetylcholine esterase anti-lipoxygenase activity of various leaf extracts Conocarpus lancifolius. Extraction was optimized from freeze dried plant quenched with liquid nitrogen using water, ethanol, methanol, hexane, ethyl acetate chloroform. Maximum extract yield, total phenolic contents flavonoid were obtained in case ethanolic extraction. The highest 2,2-diphenyl-1-picrylhydrazylradical scavenging terms IC50 value 55.26 µg/mL observed extract. acetylcholine lipoxygenase inhibitory activities (IC50) also These findings statistically significant when compared other (ρ<0.05). haemolytic % values indicated that all associated very low or negligible toxicity. epicatechin, isorhamnetin, rutin, scopoleptin, skimmianine, quercetin-3-O-α-rhamnoside, quercetin-3-O-β-glucoside, cornoside, creatinine, choline, pyruvic acid, α-hydroxybutyric phyllanthin hypophyllanthin identified as major functional metabolites C. lancifolius by 1H-NMR. probably responsible pharmacological properties may be utilized leads drug development food fortification.